![]() This work was supported by the German Competence Network on Obesity, which is funded by the German Federal Ministry of Education and Research (FKZ 01GI1122E). ![]() These results provide insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward. In addition, these findings suggest that ghrelin signaling influences hedonic-driven food intake by increasing neural reactivity during the expectation of food-related reward. ![]() Our findings show that physiological hunger stimulates food consumption by specifically increasing neural processing during the expectation (i.e., incentive salience) but not the receipt of food-related reward. Furthermore, during satiety, individual ghrelin levels were associated with increased neural processing during the expectation of food-related reward. Blood samples were collected to assess hormonal satiety signaling.įasting was associated with sensitization of the striatal reward system to the anticipation of food reward irrespective of reward magnitude. A functional connectivity analysis was performed to investigate the influence of satiety signaling on activation in neural reward networks. Every participant was scanned twice in a counterbalanced fashion, both during a fasted state (after 24 hours fasting) and satiety. ![]() Twenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks. Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. ![]()
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